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Poznato je da istovremeno uzimanje diazepama i kombinovanih oralnih kontraceptiva može dovesti do probojnog krvarenja. Mehanizam ove reakcije nije poznat. Nisu prijavljeni slučajevi neuspele kontracepcije.Oštećena funkcija i sedacija se mogu javiti i narednog jutra i nekoliko dana kasnije posle primene leka. Pacijente treba upozoriti da uticaj